CHICAGO Cheap Men's Nike Air Max 97 Silver Grey Red UK , Aug. 16 (Xinhua) -- An experimental drug combined with the traditional chemotherapy drug cisplatin destroyed a rare form of salivary gland tumor in mice and prevented a recurrence within 300 days, a University of Michigan (UM) study found.
Typically, oncologists treat this rare cancer called adenoid cystic carcinoma, or ACC, with surgery and radiation, and rarely use chemotherapy as ACC is extremely slow-growing, and chemotherapy works best on cancers where cells divide rapidly and tumors grow quickly Cheap Men's Nike Air Max 97 All Black UK , said Jacques N?r, a UM professor of dentistry, otolaryngology and biomedical engineering and principal investigator on the study.
The N?r lab treated ACC tumors with a novel drug called MI-773, and then combined MI-773 with traditional chemotherapy cisplatin. MI-773 prevents a molecular interaction that causes tumor cells to thrive by disarming the critical cancer fighting protein, p53.
Study co-author Shaomeng Wang, UM professor of medicine, pharmacology and medicinal chemistry Cheap Men's Nike Air Max 97 OG GS All Black UK , discovered MI-773.
Researchers believe that blocking that interaction sensitized ACC cancer cells to cisplatin, a drug that under normal conditions wouldn't work. When administered to the mice with ACC tumors, the cisplatin targeted and killed the bulk cells that form the tumor mass, while MI-773 killed the more resistant cancer stem cells that cause tumor recurrence and metastasis.
"This drug MI-773 prevents that interaction, so p53 can induce cell death," N?r said.
"We did not observe any recurrence in the mice that were treated with this drug after 300 days, and we observed about 62 percent recurrence in the control group that had only the surgery Cheap Men's Nike Air Max 97 All White UK ," N?r said. "It's our belief that by combining conventional chemotherapy with MI-773, a drug that kills more cancer stem cells, we can have a more effective surgery or ablation."
One limitation of the study is that about half of all ACC tumors recur only after about 10 years, and this observational period was only 300 days.
It is still too early to know how humans will respond. Besides, the drug will work primarily in tumors where p53 is normal. If p53 is mutated, which is fairly common in other tumor types, this drug won't work as well Cheap Nike Air Max 97 Summit White UK , N?r said.
ACC is a rare cancer that affects 3,000-4,000 people annually, and typically arises in the salivary glands. It's usually diagnosed at an advanced stage, is very resistant to therapy, and there's no cure.
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GUANGZHOU, Jan. 22 (Xinhua) -- It was during college that Liu Zihong first explored the feasibility of creating a wafer-thin nike air vapormax uk , bendable screen.
In 2012, Liu moved to Shenzhen City in Guangdong Province and set up Royole so that he could develop this concept. The timing was fortunate, as the Guangdong government had begun to support innovation as a way to bolster its economy, offering investment to research and development (R&D) and many preferential policies to lure talent to the province.
At the same time, technology giants like Apple, Samsung and LG were sparing no effort developing organic light-emitting diode (OLED), which promised to solve the quandary of the problems of high-definition display -- the size and portability.
Committed to his own concept nike air vapormax flyknit uk , Liu forged ahead developing his idea. Within two years, Royole had created AMOLED display. At just 0.01 mm thick, it is the thinnest HiDef display ever made in the world. While its unique flexibility means that it has the potential to be used in electronic devices, automobiles, domestic appliances and even clothes.
This is a product that will revolutionize the electronics world, Liu believed.
"With AMOLED display, you can fold an iPad into [the size of an] iPhone nike air max 2018 uk ," Liu told First Business Daily in November.
The invention has made Liu one to watch in the industry. He has been named one of the best entrepreneurs in China and is one of the top ten talented professionals in Shenzhen. Last year he was even invited to show his product to Premier Li Keqiang, a vocal champion of innovation, according to First Business Daily.
Liu partly attributes his success to government support.
"Shenzhen is like China's 'Silicon Valley,'" Liu said. "The environment is open and tolerant, and you can find almost anything you want for your career."
As the government continues to support R&D, it is no better time than now for innovators like Liu.
Guangdong Bureau of Statistics on Thursday announced that the government will spend more than 3.5 percent of its GDP on R&D, promising to keep the economic contribution of science and technology at no less than 70 percent.
"The government is helping to make market access easier for innovative products nike air max 97 womens uk ," Liu said.
China is facing an economic slowdown, with the economy in 2015 experiencing the slowest annual expansion in a quarter of a century.
With the possibility of a downturn, the Guangdong government is pursuing an innovation-driven economy.
The provincial government had increased R&D investment to 2.5 percent out of its GDP in 2015 from 1.76 percent in 2010.
"There is a dynamic mix of innovative talent in Guangdong these days thanks to preferential policies from the government," said Guo Wanda, an official with the China Development Institute.
According to Guangdong government, the province has 2.73 million people with high-end expertise, up 67.5 percent from 2010.
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